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Upon analysis, scientists found that after using the medications for 3 months, participants experienced a loss of about 9% of their starting weight

This rule allows your body to adapt slowly and minimizes side effects like nausea, fatigue, or GI distress, while still gaining the benefits of appetite regulation, insulin sensitivity, and metabolic rebalancing

Common Side Effects Hunger & injection-site reactions: Marked appetite/hunger is expected

So antagonism or genetic deletion take those receptors out of the equation, then whatever other system causes enhanced insulin secretion or protection from weight gain2