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A diet high in FODMAPs increases bacterial fermentation, increasing levels of a toxin in their cell wall called lipopolysaccharide (LPS)

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Its role in promoting tissue regeneration and enhancing nerve function can be beneficial for some individuals

Discontinuation, regain, and reinitiation (class-level, semaglutide / tirzepatide) Budini 2026 ( eClinicalMedicine ) pooled regain curve: asymptotic maximum regain 75.3% of lost weight, half-life about 23 weeks, so roughly 60% of the loss returns by 12 months and about 40% is still held at a year

It has a score of 1 on the Environmental Working Group (EWGs) skin-deep scale, indicating a low potential for cancer, allergies, immunotoxicity, developmental and reproductive toxicity, and use restrictions