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(9) In one study on murine models, the authors commented that " CJC-1295 caused an increase in total pituitary RNA and GH mRNA, suggesting that proliferation of somatotroph cells had occurred, as confirmed by immunohistochemistry images
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GLP-1 analogues differ in their duration of action, respective half-lives and route of administration and therefore require different frequencies of administration (see Figure 3)
3b) showed severe histopathological changes which are consistent with cardiotoxicity manifested as scattered chronic inflammatory cells with focal fragmentation of myocardial fibers and loss of nuclei (arrowhead)
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