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J Evol Biol 18 : 13681373

If your intake already averages 425-550mg/day, tacking on a supplement may offer little added benefit.70 Individuals with kidney or metabolic disease Elevated TMAO from excess choline is most concerning in people with reduced kidney function or metabolic disorders, where clearance is impaired.69 In these groups, some choline supplements may amplify cardiovascular risk markers

A 1-Year prospective study of the infectious etiology in patients hospitalized with acute exacerbations of COPD

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Kwon KH, Murakami A, Ohigashi H