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2.1 Exogenous and endogenous substances 2.1.1 Exogenous substances 2.1.1.1 Per- and poly-fluoroalkyl substances Perfluoroalkyl chemicals, including perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), are found in all populations worldwide, regardless of geographical location, due to their extensive use (11)