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"Tolerating well" means minimal or no nausea, no vomiting, and no significant gastrointestinal distress

Pregnancy and Breastfeeding Topical use is considered low-risk, but definitive clinical safety data are limited

Multiple CVB variants have been shown to induce cell degeneration, pyknosis, reduction of islet identity genes, and decreased insulin content and secretion in primary human islets cultured in vitro or transplanted into diabetic NOD mice ( CVB-induced cell death may be partly caused by virus-induced ER stress since ER stress negatively impacts cell function and viability, leading to T1D onset (184, 188)

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In some cases, symptoms that appear to be a simple injury may require medical evaluation