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The shots are an injection into the skin

Pull the calculated volume corresponding to the target dose (1 mcg/kg to 10 mcg/kg) into an insulin syringe (28 to 31 gauge) to minimize tissue trauma at the injection site

Localised injection near target tissue (a damaged tendon, joint, muscle) is used in musculoskeletal repair research where proximity to the injury site may enhance local angiogenesis and fibroblast activation

The only difference is FDA approval indication: Mounjaro is approved for type 2 diabetes, while Zepbound is approved for weight loss

However, less than two months later, Novo Nordisk ended the relationship in June 2025