It's a deliberate protective measure
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The following keywords and MeSH terms were employedindividually or in combinationto identify relevant studies: natural bioactive products, flavonoids, phenolics, saponins, polysaccharides, terpenoids, osteogenesis, bone regeneration, osteoporosis, osteoblasts, osteoclasts, angiogenesis, bone marrow-derived mesenchymal stem cells (BMSCs), Wnt/-catenin, BMP/Smad, phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt), Mitogen-activated protein kinase (MAPK), Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B), Janus kinase (JAK)/signal transducer and activator of transcription (STAT), Nuclear factor erythroid 2related factor 2 (Nrf2)/glutathione peroxidase 4 (GPX4), ferroptosis, oxidative stress, immune modulation, Classically activated macrophage (M1)/alternatively activated macrophage (M2) polarization, regulatory T cells (Tregs), gut microbiota, gutbone axis, Receptor activator of nuclear factor B ligand (RANKL)/osteoprotegerin (OPG), drug delivery, and biomaterial scaffolds. Boolean operators (AND, OR) were used to optimize search sensitivity and specificity
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