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This eliminates confounding from intensive lifestyle enrichment (STEP 3, SURMOUNT-3) and run-in/maintenance designs (STEP 4, SURMOUNT-4) that inflate active-arm weight loss estimates

In clinical trials, retatrutide has been administered as a once-weekly subcutaneous injection, consistent with other agents in its class (Jastreboff et al., NEJM , 2023)

This schedule helps achieve the best results for blood sugar control throughout the day

MH: No, its not just you, because I talk to women every day, and it is the rare patient who is not watching their mother not live a healthful life who is plagued with something for decades