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PLoS One 7 (11), e49418

Specifically, we focus on the Bcl-2 family, whose members control intrinsic apoptosis by regulating the permeabilization of the mitochondrial outer membrane (MOM), on members of the Gasdermin protein family that control plasma membrane (PM) permeabilization in pyroptosis, and, finally, on mixed lineage kinase domain-like (MLKL) protein, the pore-forming executor of necroptosis

3.2 Opioids Although opioids such as morphine, remifentanil, heroin, and oxycodone largely share a common pharmacologic mechanism of action, namely, acting on opioid receptors, the ability of GLP-1R to regulate the behavioral responses to these opioids varies

The absorbance value was determined by fluorescence spectrophotometer [49]

Such findings have inspired a new field of combination drug therapy in which GLP-1R and NPY2R agonists are under investigation for use in the treatment of obesity 10