MX1 was also reported to be up-regulated in COVID-19 patients ( FIGURE 7 Furthermore, the abundant cytokine IL18, the IL-1 receptor antagonist protein (IL1RN), the macrophage immunometabolism regulator MACIR and the Alpha-2-macroglobulin (A2M) were 0.6-fold lower expressed in infected cells
Notably, zinc plays a protective role at the cellular level, as it has been shown to significantly inhibit apoptosis in ATP-depleted renal cells [459]
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