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In another trial, 70 individuals with recurrent calcium kidney stones, high urine calcium concentration, and bone loss were treated with either 70 mg per week of alendronate or 70 mg per week of alendronate plus 50 mg per day of the diuretic hydrochlorothiazide

This sustained sensitivity may explain why some individuals report consistent benefits from low doses maintained over many months

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Other power players include glutathione (an antioxidant that works from within), niacinamide (perfect for evening out tone), and alpha arbutin (a gentler alternative to hydroquinone)

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