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Nutrient partitioning: IGF-1 LR3 acts similarly to insulin on nutrient uptake (glucose, amino acids) at the muscle level meaning more of what you eat gets directed toward muscle tissue

DOI: 10.2337/db10-0474 Shaefer CF Jr et al (2015): User's guide to mechanism of action and clinical use of GLP-1 receptor agonists

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Its important physiological role was initially discerned in undifferentiated human embryonic stem cells (hESCs), where ChaC2 is prominently expressed and maintains cell self-renewal and pluripotency by modulating GSH homeostasis