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The question is not simply when a patent expires but when formulary dynamics will shift against the reference product, and whether an authorized generic or co-branding arrangement with a PBM can extend meaningful commercial life beyond the formal IP exclusivity window

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Furthermore, several xenobiotics that have been shown to promote eryptosis, like lead, paclitaxel, cyclosporine, prostaglandin E 2 (PGE 2 ), curcumin, amphotericin B, dimethylfumerate, and chlorpromazine, can slow down the progression of malarial infection in mice or humans [230, 375, 404, 408,409,410,411]

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