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These studies do not establish safety, dosage, or effectiveness for human therapeutic use

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Nrf2/ARE pathway inhibits inflammatory infiltration by macrophage in rats with autoimmune myositis

Upregulation of sense gene via NAT degradation While the previously mentioned mechanisms function to upregulate the sense gene by directly acting upon the sense gene mRNA transcript, one limitation lies in the fact that uORFs only exist in approximately 50% of mammalian mRNA and within this 50%, not all are inhibitory [106, 107]