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Before & After by the Numbers: Clinical Trial Data Raw percentages from trials become more meaningful when translated into specific dose-group results and individual trajectories

Too much estrogen being metabolized through CYP1B1 into 4-OHE1(E2) and the estrogen quinones can potentially be bad if your body has slower phase II (COMT, GSTP1, GSTM1, NQO1) enzymes.[ref][ref] The connection between smoking and estrogen-related cancers: Smoking significantly increases the risk of breast cancer and prostate cancer

10.1016/j.neuropharm.2012.07.010 [DOI] [PubMed] [Google Scholar] Shukitt-Hale B, McEwen JJ, Szprengiel A, Joseph JA (2004) Effect of age on the radial arm water maze-a test of spatial learning and memory

MT-I itself is approved for long-term management of EPP [15]

(2025) Figure 2