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(2017) Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition

Lip melanoma Cutaneous lip melanoma and the rarer mucosal lip melanoma both warrant immediate referral for specialist multidisciplinary skin cancer care

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Endocrinology and Metabolism Clinics of North America, 41(2), 231247

This upregulation exhausts intracellular GSH, leading to ROS buildup and oxidative DNA damage that can ultimately generate TP53 mutations, a process that is halted when CHAC1 is knocked down (Wada et al., 2018)