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Oxidative stress is the imbalance between free radicals and the body's antioxidant reserves

Diabetes Ther 10 , 12051217 (2019)

Simultaneously, GLP-1 receptor activation stimulates glucose-dependent insulin release from pancreatic beta cells, suppresses inappropriate glucagon secretion, slows gastric emptying, and promotes satiety through central nervous system pathways

Fig.2 Pleiotropic effects of GLP1-RA leading to improvement MASLD/MASH [2] GLP-1RA in MASH Treatment: Clinical Progress Several GLP-1RAs and related agents are currently in various phases of clinical development for MASH treatment [4]

A recent study has also raised theoretical concerns that the drugs could negatively affect reproductive and sexual health