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I'd much rather see a slower, careful approval process than another medication rushed into widespread use without enough guardrails." Why Retatrutide May Not Be the Answer for Everyone Kenner also raises broader concerns about how weight-loss drugs are being framed culturally

Regular consultations help monitor progress and adjust plans as needed

GLP-1 medications work in several different ways to promote weight loss: 1) by mimicking a naturally occurring GLP-1 hormone in our GI tract, which in turn regulates our insulin and blood sugar levels, 2) by acting in the area of the brain that regulates our hunger cues, and 3) slows stomach emptying which results in feeling fuller for a longer period of time

Another meta-analysis including children ages 6-17 with obesity, type 2 diabetes, or prediabetes found that GLP-1s significantly reduced A1C and weight compared to placebo

Spike probability was significantly reduced in the PTSD-like mouse compared to the control (Fig