The STEP 8 trial (published in JAMA, 2022) enrolled 338 adults with overweight or obesity, without type 2 diabetes, and randomised them to receive either semaglutide 2.4 mg weekly or liraglutide 3.0 mg daily for 68 weeks
Now, millions are racing to get prescriptions, and experts have begun to calculate the global impact of a possibly widespread reduction in rates of obesity
Table of Contents Why Retatrutide Can Affect Your Bowel Habits Common Gastrointestinal Side Effects Explained How Long Digestive Symptoms Typically Last Managing Bowel Changes Whilst Taking Retatrutide When to Seek Medical Advice About Digestive Side Effects Talking to Your GP or Prescriber About Your Symptoms Scientific References Frequently Asked Questions Why Retatrutide Can Affect Your Bowel Habits Retatrutide alters bowel habits primarily through GLP-1 receptor activation, which slows gastric emptying and disrupts normal gut motility, causing diarrhoea or constipation depending on the individual
Thats why some providers recommend staying on the medication longer than just until the scale hits a target number
Success relies on correct injection technique, consistent adherence, and lifestyle changes
