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SUSTAIN-6 documented significant reduction in major adverse cardiovascular events in type 2 diabetes patients with established cardiovascular disease, and SELECT documented cardiovascular event reduction in obese patients without diabetes

It helps to keep in mind that 'glutathione' exists in two forms in the cell: glutathione disulfide (GSSG) and glutathione (GSH)

Exposure to ROS leads to a decline in Keap1s ubiquitinproteasome activity, resulting in Nrf2 stabilization and accumulation in the nucleus, where it activates its target genes

A., Duncan, C