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Eur Heart J 40(39):32153217 Davies MJ, DAlessio DA, Fradkin J, Kernan WN, Mathieu C, Mingrone G et al (2018) Management of Hyperglycemia in type 2 diabetes, 2018

[7] In a Bayesian network meta-analysis of 48 randomized trials and nearly 28,000 participants, the dominant gastrointestinal events were nausea (about 21.5%), diarrhea (10.6%), vomiting (9.1%), and constipation (7.9%), with semaglutide carrying one of the highest constipation risks

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Rather than pushing through exhaustion, evidence-based guidance supports adjusting intensity, protecting sleep, fueling adequately, and maintaining consistent but manageable movement