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Finally, the present study found, by assessing the reliability of subgroup analyses, that almost all subgroup analyses were unreliable, limited by the fact that both the number of included studies and the sample size were small

TFAM is almost exclusively present in a DNA-bound form (Takamatsu et al., 2002), and degradation of TFAM proteins by mitochondrial matrix proteases directly affects mtDNA copy number (Matsushima et al., 2010)