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The bioavailability of flavonoids is limited, as only a small fraction (i.e., less than 10% of the ingested quantity) can attain peak concentrations in the bloodstream within a few hours The bioavailability of flavonoids may be subject to various factors, such as ingestion of dietary fiber, macro and micronutrients, the duration of GI transit times, and composition of the gut microbiota (176, 177)

doi: 10.3389/FTOX.2021.773953 166 GabrielVZdyrskiCSahooDKDaoKBourgois-MochelAAtherlyTet al

B12 deficiency is more common than most people realize, especially in people who follow a plant-based diet, take certain medications, or have absorption issues

PubMed 11121901.

10.1166/jbn.2021.3031 118 LuanP.D'amicoD.AndreuxP