The enzymes of the non-oxidative reactions of the PPP include transaldolase (encoded by the TALDO1 gene), transketolase (encoded by the TKT gene), ribose-5-phosphate isomerase (encoded by the RPIA gene), and ribulose-5-phosphate-3-epimerase (encoded by the RPE gene)
Lastly, after showing enhanced anti-leukemic activity in both STR and LTR patient-derived CAR T cells manufactured with rapamycin, in two independent models of leukemia (Nalm6 and 018z), we were intrigued by the possible difference in overall survival of STR with rapamycin compared to the LTR with rapamycin in the Nalm6 model (Fig
Safety & Tolerability
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