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Synthetic DMARDs such as MTX, Hydroxychloroquine (HCQ), Sulfasalazine (SSZ), Clofazimine (CLO), Leflunomide (LEF), Actarit, and Azathioprine show various side effects including myelosuppression, hepatic cirrhosis, interstitial pneumonitis, and gastrointestinal disorders (Zhao et al

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