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Minimally invasive procedures include endoscopic resection removing damaged cells, radiofrequency ablation destroying abnormal tissue with heat, and cryotherapy using liquid nitrogen

Therefore, both temporal and spatial considerations of IGF-1R modulation will need to be considered in future trials with these drugs in order to clearly define the benefits and potential risks associated with this treatment, and guide development of strategies that allow for safe and effective long-term human use

They also have their own good points and risks

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