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To accurately evaluate the situation, one must consider both the immediate expenses and the potential for long-term savings

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If cold extremities persist despite these measures, patients should discuss the symptom with their prescriber

However, a consideration in the use of go/no-go criteria to stop trials (particularly in early-stage phase 1b and 2 trials) early is the tradeoff between improving efficiency and loss of opportunities to learn about the biology of AD/ADRD, which is a fundamental element of NIH-funded AD/ADRD clinical research

however, females are more affected in both the types [13, 14]