Nishioka H, Baesso I, Semenzato G, Trentin L, Rappuoli R, Del Giudice G, et al
And its one of those things where you get some injuries
Endotoxins and other inflammatory products, such as histamines, reactive oxygen (ROS), and reactive nitrogen species (RNS), increase the expression of inflammatory genes and secrete IL-1 and TNF (and occasionally IFN-) [27] (Figure 1)
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Slightly more nerdy answer: because peptides are small, they can bind directly to cell receptors and trigger specific biological effects