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But controlled human efficacy data is sparse, and the single Phase 2 trial tested oral administration rather than the subcutaneous injection most users employ today

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Among 173 RA patients with overweight or obesity who were prescribed GLP-1 agonists and actually took them, 32% showed improvement in RA disease activity after 1 year, compared with 17% of 42 patients who were also prescribed the drugs but never started them, according to Veena Ranganath, MD, MS, of the University of California Los Angeles (UCLA), and colleagues

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