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If clinical markers are not improving after an adequate trial period at therapeutic doses, the prescribing clinician should reassess the treatment plan and consider whether retatrutide remains the most appropriate option

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The SURMOUNT trials showed that participants with higher baseline BMI often ended up at higher maintenance doses (12.5mg or 15mg), while those with lower baseline BMI sometimes achieved their goals at 7.5mg or 10mg

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1997 Mar;56(3):331-41