10.1007/s00403-015-1554-2 72 GianfaldoniS.WollinaU.TirantM.TchernevG.LottiJ.SatolliF.et al (2018)
Glutathione is a molecule the body produces itself, primarily in the liver, from three amino acids: glutamic acid, cysteine and glycine
That's not a flaw it's glutathione doing its job, neutralizing the oxidative stress and lactic acid byproducts that intense training produces
The most significant marker, considered a gold standard, was F2-isoprostane and this was significantly more reduced by oral Acetylglutathione than with the IV glutathione.[11],[12] Oral S-Acetyl Glutathione, dosed 200mg daily for 7 days, AM IV 1400mg, single dose Serum and urine tested after 1 week of administration N=6, (4 female, 2 male, average age 45) Markers chosen are measures of Antioxidants F2-Isoprostane is the Gold Standard of oxidative stress markers Conclusion: Oral S-A GSH compares favourably to a one-time, equivalent dose of IV administered Glutathione GSH : Blood levels are lower in the A-GSH group as compared to the IV group because the A-GSH is being taken up by the cell.[13] This is substantiated by the following markers: F2-Iso : (F2- isoprostane ) measurement of redox status and oxidative stress
It has been proposed that during mobilization cytochrome c detaches from the IMM and dissociates from the membrane phospholipid cardiolipin