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GLP-1 therapies in neurodegenerative diseases As described above, GLP-1RAs engage multiple convergent pathways implicated across NDDs, from proteostasis and mitochondrial quality control to neuroinflammation, synapse function, and gut-brain-immune interactions

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These may include: other FDA-approved weight-loss medications structured medical weight-management programs nutrition and behavioral counseling supervised exercise interventions long-term clinical monitoring Some older medications are available in generic form and may be less expensive, although experts note they may not produce the same degree of weight loss as GLP-1 therapies

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Many metabolic changes begin to occur, which can lead to greater risk for heart disease, diabetes, metabolic syndrome