Universit de Louvain researchers found that fiber fermentation in the lower intestine creates short-chain fatty acids (SCFAs) that trigger GLP-1 secretion (PMID: 33820962)
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Overall, HT pathogenesis results from a complex interplay between innate and adaptive immunity, where breakdowns in tolerance, skewed Th1/Th17/Treg balance, and persistent autoantibody production sustain chronic inflammation and irreversible thyroid destruction
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