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Amongst these fatalities, 193 deaths from anti-CTLA-4 agents, mostly from colitis (135 cases), while fatalities from pneumonitis (333), hepatitis (115) and neurotoxic effects (50) were associated with anti-PD-1/PD-L1 use

In the healthy state, GluR2 is an ionotropic glutamate receptor (iGluR), predominantly expressed in Purkinje cells (PCs) [18], as well as at lower levels in various other brain areas, including the cerebral cortex, hippocampus, thalamus, striatum, mesencephalon, and olfactory bulb [19]

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