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Approximately equal numbers of patients were randomized to receive initial therapy with placebo, 100 mg of JANUVIA once daily, 500 mg or 1000 mg of metformin HCl twice daily, or 50 mg of sitagliptin twice daily in combination with 500 mg or 1000 mg of metformin HCl twice daily

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In this case, supplemented folic acid can cover the clinical signs of B12 insufficiency, which may delay its diagnosis and treatment, and increase the risk of neurological complications