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The development of new antimicrobial drugs is very slow, whereas AMR is steadily increasing 6

The process of deactivation leads to dissipation of energy via various transitions such as internal conversion (return to ground state), fluorescence, photoionization (removal of an electron from a molecule), phosphorescence, or intersystem crossing (transition to a metastable excited triplet state) (Fig

Upon binding, the receptor-ligand complex initiates intracellular signaling cascades involving pathways such as phosphoinositide 3-kinase (PI3K) and protein kinase B (Akt), as well as mitogen-activated protein kinase (MAPK) signaling

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Shinohara, K