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B16F10 cells were pre-treated with 10 M KA and GSH (0.11.0 mg/mL) for 4 h and then stimulated with -MSH (1 M) for 72 h

Physiol Rev 94:739777 Last K, Maharaj L, Perry J, Strauss S, Fitzgibbon J, Lister TA, Joel S (2006) The activity of methylated and non-methylated selenium species in lymphoma cell lines and primary tumours

This effect of estrogen may be due to a combination of a reduction of somatostatin's inhibitory tone, amplification of endogenous GHRH levels or its pituitary actions, and activation of additional mechanisms

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The increase of intracellular ROS is believed to correlate with the activation of nuclear factor (NF)-kappa B, a transcription activator linked to the elaboration of several cytokines (Figure 6)