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The slight acidity of the solution (pH approximately 3.04.0 at 0.1% concentration) protonates basic amino acid residues on poorly water-soluble peptides, increasing their net positive charge and improving electrostatic interaction with the surrounding aqueous solvent a mechanism that dramatically increases the solubility of many lyophilised peptide preparations that resist dissolution in neutral or alkaline aqueous conditions

Citations and Footnotes McKenzie AL, Athinarayanan SJ, McCue JJ, Adams RN, Keyes M, McCarter JP, Volek JS, Phinney SD, Hallberg SJ

10.1177/1078155220904153 164 SnavelyA

Frias 2023 Lancet combination outperforms monotherapy components in T2D + obesity Phase 2

Carey, J