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Attenuation of glomerular hyperfiltration results in prevention of long-term glomerular damage, contributing to reduce the progression of diabetic kidney disease (DKD) ( Figure 1 The increased sodium delivery to the macula densa theoretically results in low renin levels per se

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Nrf2 mediates the DNA methylation level of RANKL promoter by regulating the activity of DNA methyltransferase 3a, participating in the regulation of ferroptosis in osteoclasts and bone homeostasis