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Mutations could also lead to G6PD instability and disrupts protein folding which affects the amount of functional protein in vivo

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For nanomaterials-enhanced glucose metabolism intervention, nanotechnology provides innovative solutions to modulate tumor glucose metabolism by blocking glucose uptake, inhibiting glucose transporter [40, 41], glucose depletion [42,43,44], modulating glycolytic enzymes [45, 46], reprogramming metabolic pathways [47], and combining glucose metabolic regulation with other therapies [48, 49]