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Larazotide is studied as a zonulin antagonist / tight-junction regulator : in mechanistic work it is associated with promoting the reassembly of tight-junction proteins and the underlying actin cytoskeleton, blunting the gliadin- and zonulin-induced rise in permeability [4] [5]

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See What Is BPC-157 for a full clinical overview.

In some embodiments, the osmolarity at a target site of action (e.g., the perilymph) is about the same as the delivered osmolarity (i.e., osmolarity of materials that cross or penetrate the round window membrane) of any formulation described herein