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CYP3A4*22 decreases hepatic clearance by approximately 2030%, raising hepatotoxicity risk via increased systemic exposure [57]

Un factor que influye en el estado del glutatin es el grado de variabilidad en la capacidad de un individuo para producir glutatin, debido principalmente a la variabilidad gentica en las enzimas (glutatinn S-transferasa, la gamma-glutamil transferasa) implicadas en su produccin y/o regeneracin

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Both the American Diabetes Association and Kidney Disease Improving Global Outcomes organization provide updated pharmacological recommendations for treating T2DM in people with CKD that include the use of sodium-glucose co-transporter-2 inhibitors (SGLT2i) or glucagon-like peptide-1 receptor agonists (GLP-1 RAs)