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Practical Interpretation The mechanistic plausibility (NNMT NAD SIRT1/PGC-1 BMR & fat oxidation) is strong and consistent across preclinical models

Several currently used cancer drugs exert their anticancer activity in part through covalent inhibition of TrxR 21 and two covalent TrxR inhibitors are currently in clinical trials 68

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2 Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (Promise), University of Palermo, Palermo, Italy Correspondence: Ali A Rizvi, Department of Medicine, University of Central Florida College of Medicine, 3400 Quadrangle Blvd, Orlando, Florida, 32817, USA, Tel +1 803-609-1935, Fax +1 407-882-4799, Email [email protected] Abstract: The incretin pathway is a self-regulating feedback system connecting the gut with the brain, pancreas, and liver