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10.1248/bpb.b15-00331 158 NiuC.AisaH

Results and discussion Chemistry and biological experiments Design and synthesis of acryl-bearing GDP-based inhibitors We started with a detailed structural analysis based on the previously published co-crystal structures of KRAS G13C in complex with eda-GDP and bda-GDP (PDB IDs 7OK3 and 7OK4, respectively)