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1 Introduction Over the past two decades, significant advances in cancer therapy, including molecularly targeted agents, immune checkpoint inhibitors, and precision oncology strategies, have improved initial response rates and short-term clinical outcomes across multiple malignancies ( 1.1 The central challenge: tumor heterogeneity as the root cause of therapeutic failure Cancer progression and treatment failure are best understood through the lens of cellular heterogeneity rather than uniform malignant behavior

Immunity Inflamm Dis 12:e70051 Luger T, Amagai M, Dreno B, Dagnelie M-A, Liao W, Kabashima K, Schikowski T, Proksch E, Elias PM, Simon M (2021) Atopic dermatitis: role of the skin barrier, environment, microbiome, and therapeutic agents

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