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Paracetamol absorption studies have shown delayed time to maximum concentration but no significant change in overall exposure when taken with GLP-1 agonists

Some people already experience delayed gastric emptying or gastroparesis, and Ozempic may increase the risk of gastroparesis symptoms or make them worse

Plus, a 2016 study found that B12 supplements that are mixed with saliva are broken down and absorbed better than supplements that are swallowed whole

The body clears semaglutide gradually on its own

Ideal timing for testing: Before starting your GLP-1 medication (baseline) 4-6 weeks after starting treatment After any dose increase Quarterly during stable dosing Immediately if warning symptoms appear People at higher risk for electrolyte problems include those over 65, anyone with kidney disease, heart failure patients, people taking diuretics, and anyone with persistent GI symptoms lasting beyond the first 8-12 weeks of treatment