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Organoids derived from ectopic endometriosis lesions have shown promising utility in modeling disease-specific characteristics, including the altered expression of ECM-receptor interaction genes ( COL3A1 , FN1 , ITGA11 , LAMA2 ), WNT-pathway genes ( CTNNA2 , LEF1 , WNT11) and hormone-responsive genes ( HSD11B1 , LIFR , PGR , PRLR ) [40, 55, 64]

In primary human lung carcinomas, IL-17 was linked to the cancer cell production of a variety of pro-angiogenic factors, such as IL-6, IL-8, and VEGF (132), as well as to the upregulation of VEGF-C, a growth factor involved in lymphangiogenesis (133)

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Indeed, metformin enhances the chemosensitivity of ALL by suppressing the protein kinase B/mammalian target of rapamycin (AKT-mTOR) signaling cascade, which is mediated via the activation of adenosine monophosphate-activated protein kinase (AMPK) 9