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In our study, FOXO4-DRI selectively induced apoptosis in senescent keloid fibroblasts by promoting the relocation of p53-pS15 from the nucleus to the cytoplasm, exhibiting similar clearance efficiency to that in normal skin fibroblasts
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Similarly, mutations in p62 result in decreased elimination of misfolded and ubiquitinated proteins (Yue and Yang, 2013)
Kruse T, Dahl K, Schaffer L, et al
However, free radicals generated as a result of metabolic events can accumulate in the body and lead to the deterioration of the egg or sperm
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