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Necroptosis and pyroptosis are characterized by the formation of plasma membrane pores via caspase-1, which leads to the pro-inflammatory cytokines release and cell lysis, and thus controls the inflammatory response

This allows the glutathione to bypass the harsh environment of the stomach and deliver the "master antioxidant" directly into the cells

10.1096/fj.10-162438 FASEB J

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Stomach acid is extremely powerful (its used to break down food after all), so this disorder can cause all sorts of long-term problems if silent reflux is chronic and goes untreated